6VBZ
Crystal structure of the rat MLKL pseudokinase domain
Summary for 6VBZ
| Entry DOI | 10.2210/pdb6vbz/pdb |
| Descriptor | Mixed lineage kinase domain-like pseudokinase, MANGANESE (II) ION (3 entities in total) |
| Functional Keywords | cell death, necroptosis, pseudokinase, transferase |
| Biological source | Rattus norvegicus (Rat) |
| Total number of polymer chains | 2 |
| Total formula weight | 66993.85 |
| Authors | Davies, K.A.,Czabotar, P.E. (deposition date: 2019-12-19, release date: 2020-07-08, Last modification date: 2023-10-11) |
| Primary citation | Davies, K.A.,Fitzgibbon, C.,Young, S.N.,Garnish, S.E.,Yeung, W.,Coursier, D.,Birkinshaw, R.W.,Sandow, J.J.,Lehmann, W.I.L.,Liang, L.Y.,Lucet, I.S.,Chalmers, J.D.,Patrick, W.M.,Kannan, N.,Petrie, E.J.,Czabotar, P.E.,Murphy, J.M. Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues. Nat Commun, 11:3060-3060, 2020 Cited by PubMed: 32561735DOI: 10.1038/s41467-020-16823-3 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.192 Å) |
Structure validation
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