6VBZ

Crystal structure of the rat MLKL pseudokinase domain

6VBZ の概要

• エントリーDOI: 10.2210/pdb6vbz/pdb
• 分子名称: Mixed lineage kinase domain-like pseudokinase, MANGANESE (II) ION (3 entities in total)
• 機能のキーワード: cell death, necroptosis, pseudokinase, transferase
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66993.85

構造登録者

Davies, K.A.,Czabotar, P.E. (登録日: 2019-12-19, 公開日: 2020-07-08, 最終更新日: 2023-10-11)

• 主引用文献: Davies, K.A.,Fitzgibbon, C.,Young, S.N.,Garnish, S.E.,Yeung, W.,Coursier, D.,Birkinshaw, R.W.,Sandow, J.J.,Lehmann, W.I.L.,Liang, L.Y.,Lucet, I.S.,Chalmers, J.D.,Patrick, W.M.,Kannan, N.,Petrie, E.J.,Czabotar, P.E.,Murphy, J.M.; Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.; Nat Commun, 11:3060-3060, 2020; PubMed: 32561735; DOI: 10.1038/s41467-020-16823-3

実験手法

X-RAY DIFFRACTION (2.192 Å)