6VBL

Crystal structure of the transpeptidase domain of PBP2 from the Neisseria gonorrhoeae cephalosporin decreased susceptibility strain 35/02

6VBL の概要

• エントリーDOI: 10.2210/pdb6vbl/pdb
• 分子名称: Probable peptidoglycan D,D-transpeptidase PenA (2 entities in total)
• 機能のキーワード: penicillin-binding protein, transpeptidase domain, antibiotic resistance, hydrolase
• 由来する生物種: Neisseria gonorrhoeae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35331.38

構造登録者

Singh, A.,Davies, C. (登録日: 2019-12-19, 公開日: 2020-04-15, 最終更新日: 2023-10-11)

• 主引用文献: Singh, A.,Turner, J.,Tomberg, J.,Fedarovich, A.,Unemo, M.,Nicholas, R.A.,Davies, C.; Mutations in Neisseria gonorrhoeae penicillin-binding protein 2 associated with extended-spectrum cephalosporin resistance create an energetic barrier against acylation via restriction of protein dynamics; J.Biol.Chem., 2020

実験手法

X-RAY DIFFRACTION (1.93 Å)