6VB9

Covalent adduct of cis-2,3-epoxysuccinic acid with Isocitrate Lyase-1 from Mycobacterium tuberculosis

6VB9 の概要

• エントリーDOI: 10.2210/pdb6vb9/pdb
• 分子名称: Isocitrate lyase, MAGNESIUM ION, OXALIC ACID, ... (6 entities in total)
• 機能のキーワード: enzyme, covalent inhibitor, substrate analog, structural genomics, psi-biology, tb structural genomics consortium, tbsgc, lyase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 191477.95

構造登録者

Krieger, I.V.,Pham, T.V.,Meek, T.D.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (登録日: 2019-12-18, 公開日: 2020-12-30, 最終更新日: 2023-10-11)

• 主引用文献: Pham, T.V.,Mellott, D.M.,Moghadamchargari, Z.,Chen, K.,Krieger, I.,Laganowsky, A.,Sacchettini, J.C.,Meek, T.D.; Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis -2,3-Epoxy-Succinic Acid.; Acs Chem.Biol., 16:463-470, 2021; PubMed: 33688722; DOI: 10.1021/acschembio.0c00740

実験手法

X-RAY DIFFRACTION (1.881 Å)