6VA9

Crystal structure of glucose-6-phosphate dehydrogenase R393H mutant in complex with catalytic NADP+

6VA9 の概要

• エントリーDOI: 10.2210/pdb6va9/pdb
• 分子名称: Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (2 entities in total)
• 機能のキーワード: dehydrogenase, nadp+, rossmann-fold, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60056.94

構造登録者

Horikoshi, N.,Mochly-Rosen, D.,Wakatsuki, S. (登録日: 2019-12-17, 公開日: 2021-01-27, 最終更新日: 2023-10-11)

• 主引用文献: Horikoshi, N.,Hwang, S.,Gati, C.,Matsui, T.,Castillo-Orellana, C.,Raub, A.G.,Garcia, A.A.,Jabbarpour, F.,Batyuk, A.,Broweleit, J.,Xiang, X.,Chiang, A.,Broweleit, R.,Vohringer-Martinez, E.,Mochly-Rosen, D.,Wakatsuki, S.; Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 33468660; DOI: 10.1073/pnas.2022790118

実験手法

X-RAY DIFFRACTION (3.95 Å)