6V90

Crystal structure of the p300 acetyltransferase domain with AcCoA competitive inhibitor 12

6V90 の概要

• エントリーDOI: 10.2210/pdb6v90/pdb
• 分子名称: Histone acetyltransferase p300, (2R)-2-{[2-(4-cyanophenyl)ethyl]amino}-N-[5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl]-2-phenylacetamide, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: epigenetics, chromatin, writer, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41028.27

構造登録者

Gardberg, A.S. (登録日: 2019-12-12, 公開日: 2020-04-01, 最終更新日: 2024-04-03)

• 主引用文献: Huhn, A.J.,Gardberg, A.S.,Poy, F.,Brucelle, F.,Vivat, V.,Cantone, N.,Patel, G.,Patel, C.,Cummings, R.,Sims, R.,Levell, J.,Audia, J.E.,Bommi-Reddy, A.,Wilson, J.E.; Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.; Chemmedchem, 15:955-960, 2020; PubMed: 32181984; DOI: 10.1002/cmdc.202000007

実験手法

X-RAY DIFFRACTION (2.04 Å)