6V8B

Crystal structure of the p300 acetyltransferase domain with AcCoA competitive inhibitor 1

6V8B の概要

• エントリーDOI: 10.2210/pdb6v8b/pdb
• 分子名称: Histone acetyltransferase p300, 4-(2-{[(1R)-2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino}ethyl)benzene-1-sulfonamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: epigenetics, chromatin, writer, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40964.67

構造登録者

Gardberg, A.S. (登録日: 2019-12-10, 公開日: 2020-04-01, 最終更新日: 2024-04-03)

• 主引用文献: Huhn, A.J.,Gardberg, A.S.,Poy, F.,Brucelle, F.,Vivat, V.,Cantone, N.,Patel, G.,Patel, C.,Cummings, R.,Sims, R.,Levell, J.,Audia, J.E.,Bommi-Reddy, A.,Wilson, J.E.; Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.; Chemmedchem, 15:955-960, 2020; PubMed: 32181984; DOI: 10.1002/cmdc.202000007

実験手法

X-RAY DIFFRACTION (3.13 Å)