6V7A

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with NF2657

Summary for 6V7A

Entry DOI	10.2210/pdb6v7a/pdb
Descriptor	Hdac6 protein, ZINC ION, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	histone deacetylase, hydrolase
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	1
Total formula weight	40780.53
Authors	Osko, J.D.,Christianson, D.W. (deposition date: 2019-12-08, release date: 2020-12-02, Last modification date: 2023-10-11)
Primary citation	Saraswati, A.P.,Relitti, N.,Brindisi, M.,Osko, J.D.,Chemi, G.,Federico, S.,Grillo, A.,Brogi, S.,McCabe, N.H.,Turkington, R.C.,Ibrahim, O.,O'Sullivan, J.,Lamponi, S.,Ghanim, M.,Kelly, V.P.,Zisterer, D.,Amet, R.,Hannon Barroeta, P.,Vanni, F.,Ulivieri, C.,Herp, D.,Sarno, F.,Di Costanzo, A.,Saccoccia, F.,Ruberti, G.,Jung, M.,Altucci, L.,Gemma, S.,Butini, S.,Christianson, D.W.,Campiani, G. Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation. Acs Med.Chem.Lett., 11:2268-2276, 2020 Cited by PubMed: 33214839 DOI: 10.1021/acsmedchemlett.0c00395 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08741757573 Å)

Structure validation