6V7A

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with NF2657

6V7A の概要

• エントリーDOI: 10.2210/pdb6v7a/pdb
• 分子名称: Hdac6 protein, ZINC ION, POTASSIUM ION, ... (5 entities in total)
• 機能のキーワード: histone deacetylase, hydrolase
• 由来する生物種: Danio rerio (Zebrafish)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40780.53

構造登録者

Osko, J.D.,Christianson, D.W. (登録日: 2019-12-08, 公開日: 2020-12-02, 最終更新日: 2023-10-11)

• 主引用文献: Saraswati, A.P.,Relitti, N.,Brindisi, M.,Osko, J.D.,Chemi, G.,Federico, S.,Grillo, A.,Brogi, S.,McCabe, N.H.,Turkington, R.C.,Ibrahim, O.,O'Sullivan, J.,Lamponi, S.,Ghanim, M.,Kelly, V.P.,Zisterer, D.,Amet, R.,Hannon Barroeta, P.,Vanni, F.,Ulivieri, C.,Herp, D.,Sarno, F.,Di Costanzo, A.,Saccoccia, F.,Ruberti, G.,Jung, M.,Altucci, L.,Gemma, S.,Butini, S.,Christianson, D.W.,Campiani, G.; Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation.; Acs Med.Chem.Lett., 11:2268-2276, 2020; PubMed: 33214839; DOI: 10.1021/acsmedchemlett.0c00395

実験手法

X-RAY DIFFRACTION (2.08741757573 Å)