6V79
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with NF2376
Summary for 6V79
Entry DOI | 10.2210/pdb6v79/pdb |
Descriptor | Hdac6 protein, ZINC ION, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | histone deacetylase, hydrolase |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 2 |
Total formula weight | 81667.14 |
Authors | Osko, J.D.,Christianson, D.W. (deposition date: 2019-12-08, release date: 2020-12-02, Last modification date: 2023-10-11) |
Primary citation | Campiani, G.,Cavella, C.,Osko, J.D.,Brindisi, M.,Relitti, N.,Brogi, S.,Saraswati, A.P.,Federico, S.,Chemi, G.,Maramai, S.,Carullo, G.,Jaeger, B.,Carleo, A.,Benedetti, R.,Sarno, F.,Lamponi, S.,Rottoli, P.,Bargagli, E.,Bertucci, C.,Tedesco, D.,Herp, D.,Senger, J.,Ruberti, G.,Saccoccia, F.,Saponara, S.,Gorelli, B.,Valoti, M.,Kennedy, B.,Sundaramurthi, H.,Butini, S.,Jung, M.,Roach, K.M.,Altucci, L.,Bradding, P.,Christianson, D.W.,Gemma, S.,Prasse, A. Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors. J.Med.Chem., 64:9960-9988, 2021 Cited by PubMed: 34251197DOI: 10.1021/acs.jmedchem.1c00184 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03951514036 Å) |
Structure validation
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