6V79

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with NF2376

Summary for 6V79

• Entry DOI: 10.2210/pdb6v79/pdb
• Descriptor: Hdac6 protein, ZINC ION, POTASSIUM ION, ... (6 entities in total)
• Functional Keywords: histone deacetylase, hydrolase
• Biological source: Danio rerio (Zebrafish)
• Total number of polymer chains: 2
• Total formula weight: 81667.14

Authors

Osko, J.D.,Christianson, D.W. (deposition date: 2019-12-08, release date: 2020-12-02, Last modification date: 2023-10-11)

• Primary citation: Campiani, G.,Cavella, C.,Osko, J.D.,Brindisi, M.,Relitti, N.,Brogi, S.,Saraswati, A.P.,Federico, S.,Chemi, G.,Maramai, S.,Carullo, G.,Jaeger, B.,Carleo, A.,Benedetti, R.,Sarno, F.,Lamponi, S.,Rottoli, P.,Bargagli, E.,Bertucci, C.,Tedesco, D.,Herp, D.,Senger, J.,Ruberti, G.,Saccoccia, F.,Saponara, S.,Gorelli, B.,Valoti, M.,Kennedy, B.,Sundaramurthi, H.,Butini, S.,Jung, M.,Roach, K.M.,Altucci, L.,Bradding, P.,Christianson, D.W.,Gemma, S.,Prasse, A.; Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors.; J.Med.Chem., 64:9960-9988, 2021; PubMed: 34251197; DOI: 10.1021/acs.jmedchem.1c00184

Experimental method

X-RAY DIFFRACTION (2.03951514036 Å)