6V6Z
Crystal structure of N-[(4-methoxyphenyl)sulfonyl]-N-(4-{[(4-methoxyphenyl)sulfonyl]amino}naphthalen-1-yl)glycine bound to human Keap1 Kelch domain
Summary for 6V6Z
Entry DOI | 10.2210/pdb6v6z/pdb |
Descriptor | Kelch-like ECH-associated protein 1, FORMIC ACID, N-[(4-methoxyphenyl)sulfonyl]-N-(4-{[(4-methoxyphenyl)sulfonyl]amino}naphthalen-1-yl)glycine, ... (7 entities in total) |
Functional Keywords | protein-protein interaction inhibitor, keap1, nrf2 activator, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 132025.88 |
Authors | Lazzara, P.R.,David, B.P.,Ankireddy, A.,Richardson, B.G.,Dye, K.,Ratia, K.M.,Reddy, S.P.,Moore, T.W. (deposition date: 2019-12-06, release date: 2020-04-29, Last modification date: 2023-10-11) |
Primary citation | Lazzara, P.R.,Jain, A.D.,Maldonado, A.C.,Richardson, B.,Skowron, K.J.,David, B.P.,Siddiqui, Z.,Ratia, K.M.,Moore, T.W. Synthesis and Evaluation of Noncovalent Naphthalene-Based KEAP1-NRF2 Inhibitors. Acs Med.Chem.Lett., 11:521-527, 2020 Cited by PubMed: 32292559DOI: 10.1021/acsmedchemlett.9b00631 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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