6V6Z

Crystal structure of N-[(4-methoxyphenyl)sulfonyl]-N-(4-{[(4-methoxyphenyl)sulfonyl]amino}naphthalen-1-yl)glycine bound to human Keap1 Kelch domain

6V6Z の概要

• エントリーDOI: 10.2210/pdb6v6z/pdb
• 分子名称: Kelch-like ECH-associated protein 1, FORMIC ACID, N-[(4-methoxyphenyl)sulfonyl]-N-(4-{[(4-methoxyphenyl)sulfonyl]amino}naphthalen-1-yl)glycine, ... (7 entities in total)
• 機能のキーワード: protein-protein interaction inhibitor, keap1, nrf2 activator, protein binding-inhibitor complex, protein binding/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132025.88

構造登録者

Lazzara, P.R.,David, B.P.,Ankireddy, A.,Richardson, B.G.,Dye, K.,Ratia, K.M.,Reddy, S.P.,Moore, T.W. (登録日: 2019-12-06, 公開日: 2020-04-29, 最終更新日: 2023-10-11)

• 主引用文献: Lazzara, P.R.,Jain, A.D.,Maldonado, A.C.,Richardson, B.,Skowron, K.J.,David, B.P.,Siddiqui, Z.,Ratia, K.M.,Moore, T.W.; Synthesis and Evaluation of Noncovalent Naphthalene-Based KEAP1-NRF2 Inhibitors.; Acs Med.Chem.Lett., 11:521-527, 2020; PubMed: 32292559; DOI: 10.1021/acsmedchemlett.9b00631

実験手法

X-RAY DIFFRACTION (1.6 Å)