6V0X
Crystal structure of the bromodomain of human BRD9 bound to sunitinib
Summary for 6V0X
| Entry DOI | 10.2210/pdb6v0x/pdb |
| Descriptor | Bromodomain-containing protein 9, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide (3 entities in total) |
| Functional Keywords | sunitinib, brd9, mswi/snf, baf, non-bet, brd, gene regulation |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 14648.24 |
| Authors | Karim, M.R.,Chan, A.,Zhu, J.Y.,Schonbrunn, E. (deposition date: 2019-11-19, release date: 2020-03-11, Last modification date: 2023-10-11) |
| Primary citation | Karim, R.M.,Chan, A.,Zhu, J.Y.,Schonbrunn, E. Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J.Med.Chem., 63:3227-3237, 2020 Cited by PubMed: 32091206DOI: 10.1021/acs.jmedchem.9b01980 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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