6V04

DynU16 crystal structure, a putative protein in the dynemicin biosynthetic locus

6V04 の概要

• エントリーDOI: 10.2210/pdb6v04/pdb
• 分子名称: Uncharacterized SRPBCC domain-containing protein, SODIUM ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: dynemicin, start domain, srpbcc domain, cyclase/aromatase, unknown function
• 由来する生物種: Micromonospora chersina
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32089.38

構造登録者

Alvarado, S.K.,Miller, M.D.,Bhardwaj, M.,Thorson, J.S.,Van Lanen, S.G.,Phillips Jr., G.N. (登録日: 2019-11-18, 公開日: 2020-11-18, 最終更新日: 2024-05-22)

主引用文献

Alvarado, S.K.,Miller, M.D.,Bhardwaj, M.,Thorson, J.S.,Van Lanen, S.G.,Phillips Jr., G.N.
Structural characterization of DynU16, a START/Bet v1-like protein involved in dynemicin biosynthesis.
Acta Crystallogr.,Sect.F, 77:328-333, 2021

PubMed Abstract: The 1.5 Å resolution crystal structure of DynU16, a protein identified in the dynemicin-biosynthetic gene cluster, is reported. The structure adopts a di-domain helix-grip fold with a uniquely positioned open cavity connecting the domains. The elongated dimensions of the cavity appear to be compatible with the geometry of a linear polyene, suggesting the involvement of DynU16 in the upstream steps of dynemicin biosynthesis.

PubMed: 34605436
DOI: 10.1107/S2053230X21008943

実験手法

X-RAY DIFFRACTION (1.5 Å)