6UYF

Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v1 redesigned core from genotype 6a bound to broadly neutralizing antibody AR3B

6UYF の概要

• エントリーDOI: 10.2210/pdb6uyf/pdb
• 分子名称: Fab AR3B heavy chain, Fab AR3B light chain, Envelope glycoprotein E2, ... (7 entities in total)
• 機能のキーワード: hcv, e2 core, vaccine design, self-assembly nanoparticle, broadly neutralizing antibodies, bnabs, viral protein-immune system complex, viral proein-immune system complex, viral proein/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 68888.72

構造登録者

Tzarum, N.,Wilson, I.A.,Zhu, J. (登録日: 2019-11-13, 公開日: 2020-04-22, 最終更新日: 2023-10-11)

• 主引用文献: He, L.,Tzarum, N.,Lin, X.,Shapero, B.,Sou, C.,Mann, C.J.,Stano, A.,Zhang, L.,Nagy, K.,Giang, E.,Law, M.,Wilson, I.A.,Zhu, J.; Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines.; Sci Adv, 6:eaaz6225-eaaz6225, 2020; PubMed: 32494617; DOI: 10.1126/sciadv.aaz6225

実験手法

X-RAY DIFFRACTION (2.06 Å)