6UXY

PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 8

6UXY の概要

• エントリーDOI: 10.2210/pdb6uxy/pdb
• 関連するPDBエントリー: 6UXX
• 分子名称: Protein arginine N-methyltransferase 5, Methylosome protein 50, (5R)-2-amino-5-(2-cyclohexylethyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one, ... (6 entities in total)
• 機能のキーワード: methyltransferase, prmt5, protein arginine methyltransferase 5, allosteric inhibition, peptide competitive, sam competitive, transferase, transferase-transcription complex, transferase/transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 112079.60

構造登録者

Palte, R.L.,Schneider, S.E. (登録日: 2019-11-08, 公開日: 2020-08-19, 最終更新日: 2023-10-11)

• 主引用文献: Palte, R.L.,Schneider, S.E.,Altman, M.D.,Hayes, R.P.,Kawamura, S.,Lacey, B.M.,Mansueto, M.S.,Reutershan, M.,Siliphaivanh, P.,Sondey, C.,Xu, H.,Xu, Z.,Ye, Y.,Machacek, M.R.; Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).; Acs Med.Chem.Lett., 11:1688-1693, 2020; PubMed: 32944135; DOI: 10.1021/acsmedchemlett.9b00525

実験手法

X-RAY DIFFRACTION (2.57 Å)