6UXR

Crystal structure of BAK core domain BH3-groove-dimer in complex with LysoPC

Summary for 6UXR

Entry DOI	10.2210/pdb6uxr/pdb
Descriptor	Bcl-2 homologous antagonist/killer, [(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoate, TETRAETHYLENE GLYCOL, ... (5 entities in total)
Functional Keywords	pore-forming protein, apoptosis
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	20789.57
Authors	Cowan, A.D.,Colman, P.M.,Czabotar, P.E. (deposition date: 2019-11-07, release date: 2020-09-02, Last modification date: 2023-10-11)
Primary citation	Cowan, A.D.,Smith, N.A.,Sandow, J.J.,Kapp, E.A.,Rustam, Y.H.,Murphy, J.M.,Brouwer, J.M.,Bernardini, J.P.,Roy, M.J.,Wardak, A.Z.,Tan, I.K.,Webb, A.I.,Gulbis, J.M.,Smith, B.J.,Reid, G.E.,Dewson, G.,Colman, P.M.,Czabotar, P.E. BAK core dimers bind lipids and can be bridged by them. Nat.Struct.Mol.Biol., 27:1024-1031, 2020 Cited by PubMed: 32929280 DOI: 10.1038/s41594-020-0494-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation