6UWY
DYRK1A bound to a harmine derivative
Summary for 6UWY
Entry DOI | 10.2210/pdb6uwy/pdb |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 4-(7-methoxy-1-methyl-9H-beta-carbolin-9-yl)butanamide, TETRAETHYLENE GLYCOL, ... (4 entities in total) |
Functional Keywords | kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 171652.03 |
Authors | Khamrui, S.,Lazarus, M.B. (deposition date: 2019-11-05, release date: 2020-02-12, Last modification date: 2023-11-15) |
Primary citation | Kumar, K.,Wang, P.,Wilson, J.,Zlatanic, V.,Berrouet, C.,Khamrui, S.,Secor, C.,Swartz, E.A.,Lazarus, M.,Sanchez, R.,Stewart, A.F.,Garcia-Ocana, A.,DeVita, R.J. Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human beta-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor. J.Med.Chem., 63:2986-3003, 2020 Cited by PubMed: 32003560DOI: 10.1021/acs.jmedchem.9b01379 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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