6UWY

DYRK1A bound to a harmine derivative

6UWY の概要

• エントリーDOI: 10.2210/pdb6uwy/pdb
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 4-(7-methoxy-1-methyl-9H-beta-carbolin-9-yl)butanamide, TETRAETHYLENE GLYCOL, ... (4 entities in total)
• 機能のキーワード: kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 171652.03

構造登録者

Khamrui, S.,Lazarus, M.B. (登録日: 2019-11-05, 公開日: 2020-02-12, 最終更新日: 2023-11-15)

• 主引用文献: Kumar, K.,Wang, P.,Wilson, J.,Zlatanic, V.,Berrouet, C.,Khamrui, S.,Secor, C.,Swartz, E.A.,Lazarus, M.,Sanchez, R.,Stewart, A.F.,Garcia-Ocana, A.,DeVita, R.J.; Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human beta-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor.; J.Med.Chem., 63:2986-3003, 2020; PubMed: 32003560; DOI: 10.1021/acs.jmedchem.9b01379

実験手法

X-RAY DIFFRACTION (2.95 Å)