6UVK
OXA-48 bound by inhibitor CDD-97
Summary for 6UVK
Entry DOI | 10.2210/pdb6uvk/pdb |
Descriptor | Beta-lactamase, 1-{4-[4-(2-ethoxyphenyl)piperazin-1-yl]-1,3,5-triazin-2-yl}piperidine-4-carboxylic acid, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | inhibitor, beta-lactamase, oxa-48, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 4 |
Total formula weight | 115152.74 |
Authors | Taylor, D.M.,Hu, L.,Prasad, B.V.V.,Sankaran, B.,Palzkill, T.G. (deposition date: 2019-11-02, release date: 2020-05-06, Last modification date: 2023-11-15) |
Primary citation | Taylor, D.M.,Anglin, J.,Park, S.,Ucisik, M.N.,Faver, J.C.,Simmons, N.,Jin, Z.,Palaniappan, M.,Nyshadham, P.,Li, F.,Campbell, J.,Hu, L.,Sankaran, B.,Prasad, B.V.V.,Huang, H.,Matzuk, M.M.,Palzkill, T. Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries. Acs Infect Dis., 6:1214-1227, 2020 Cited by PubMed: 32182432DOI: 10.1021/acsinfecdis.0c00015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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