6UUL

Crystal structure of broad and potent HIV-1 neutralizing antibody 438-D5

Summary for 6UUL

Entry DOI	10.2210/pdb6uul/pdb
Related	6UTK
Descriptor	D5 Fab Heavy Chain, D5 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	v3 glycan supersite, human antibody, immune system, anti-hiv neutralizing antibody
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	98232.99
Authors	Kumar, S.,Wilson, I.A. (deposition date: 2019-10-30, release date: 2020-09-23, Last modification date: 2023-10-11)
Primary citation	Kumar, S.,Ju, B.,Shapero, B.,Lin, X.,Ren, L.,Zhang, L.,Li, D.,Zhou, Z.,Feng, Y.,Sou, C.,Mann, C.J.,Hao, Y.,Sarkar, A.,Hou, J.,Nunnally, C.,Hong, K.,Wang, S.,Ge, X.,Su, B.,Landais, E.,Sok, D.,Zwick, M.B.,He, L.,Zhu, J.,Wilson, I.A.,Shao, Y. A V H 1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite. Sci Adv, 6:-, 2020 Cited by PubMed: 32938661 DOI: 10.1126/sciadv.abb1328 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.06 Å)

Structure validation