6URV

Crystal structure of Yellow Fever Virus NS2B-NS3 protease domain

6URV の概要

• エントリーDOI: 10.2210/pdb6urv/pdb
• 分子名称: NS2B, NS3 protease (3 entities in total)
• 機能のキーワード: yellow fever, protease, ns3, flavivirus flaviviruses, yfv, peptide binding protein, viral protein
• 由来する生物種: Yellow fever virus; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 97524.26

構造登録者

Noske, G.D.,Gawriljuk, V.F.O.,Fernandes, R.S.,Oliva, G.,Godoy, A.S. (登録日: 2019-10-24, 公開日: 2020-01-22, 最終更新日: 2023-10-11)

主引用文献

Noske, G.D.,Gawriljuk, V.O.,Fernandes, R.S.,Furtado, N.D.,Bonaldo, M.C.,Oliva, G.,Godoy, A.S.
Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus.
Biochim Biophys Acta Gen Subj, 1864:129521-129521, 2020

PubMed Abstract: The Yellow Fever virus (YFV) is transmitted by mosquitos and causes an infection with symptoms including fever, headaches and nausea. In 20-50% of the cases, the disease may evolve to a visceral stage, reaching high mortality rates. YFV NS2B-NS3 protease has been identified as an important drug target.

PubMed: 31931019
DOI: 10.1016/j.bbagen.2020.129521

実験手法

X-RAY DIFFRACTION (2.9 Å)