6UR8

CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline

Summary for 6UR8

• Entry DOI: 10.2210/pdb6ur8/pdb
• EMDB information: 20857
• Descriptor: Chimera of soluble cytochrome b562 (BRIL) and neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: acetylcholine receptor, nicotine, varenicline, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 252584.21

Authors

Alvarez, F.J.D.,Mukherjee, S.,Han, S.,Ammirati, M.,Kossiakoff, A.A. (deposition date: 2019-10-22, release date: 2020-04-29, Last modification date: 2020-07-29)

• Primary citation: Mukherjee, S.,Erramilli, S.K.,Ammirati, M.,Alvarez, F.J.D.,Fennell, K.F.,Purdy, M.D.,Skrobek, B.M.,Radziwon, K.,Coukos, J.,Kang, Y.,Dutka, P.,Gao, X.,Qiu, X.,Yeager, M.,Eric Xu, H.,Han, S.,Kossiakoff, A.A.; Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.; Nat Commun, 11:1598-1598, 2020; PubMed: 32221310; DOI: 10.1038/s41467-020-15363-0

Experimental method

ELECTRON MICROSCOPY (3.71 Å)