6UMD

Crystal structure of human GAC in complex with inhibitor UPGL00012

Summary for 6UMD

• Entry DOI: 10.2210/pdb6umd/pdb
• Descriptor: Glutaminase kidney isoform, mitochondrial, 2-(pyridin-3-yl)-N-(5-{4-[(5-{[(pyridin-3-yl)acetyl]amino}-1,3,4-thiadiazol-2-yl)amino]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)acetamide (3 entities in total)
• Functional Keywords: inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 233281.44

Authors

Huang, Q.,Cerione, R.A. (deposition date: 2019-10-09, release date: 2020-10-14, Last modification date: 2023-10-11)

• Primary citation: Huang, Q.,Cerione, R.A.; Crystal structure of human GAC in complex with inhibitor UPGL00012; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)