6UL8

RIP2 kinase catalytic domain complex with (5S,6S,8R)-2-(benzo[d]thiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8-methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide

6UL8 の概要

• エントリーDOI: 10.2210/pdb6ul8/pdb
• 分子名称: Receptor-interacting serine/threonine-protein kinase 2, (5S,6S,8R)-2-(1,3-benzothiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8-methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71139.84

構造登録者

Shewchuk, L.M.,Convery, M.A. (登録日: 2019-10-07, 公開日: 2019-12-04, 最終更新日: 2023-10-11)

主引用文献

Haffner, C.D.,Charnley, A.K.,Aquino, C.J.,Casillas, L.,Convery, M.A.,Cox, J.A.,Elban, M.A.,Goodwin, N.C.,Gough, P.J.,Haile, P.A.,Hughes, T.V.,Knapp-Reed, B.,Kreatsoulas, C.,Lakdawala, A.S.,Li, H.,Lian, Y.,Lipshutz, D.,Mehlmann, J.F.,Ouellette, M.,Romano, J.,Shewchuk, L.,Shu, A.,Votta, B.J.,Zhou, H.,Bertin, J.,Marquis, R.W.
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
Acs Med.Chem.Lett., 10:1518-1523, 2019

PubMed Abstract: Herein we report the discovery of pyrazolocarboxamides as novel, potent, and kinase selective inhibitors of receptor interacting protein 2 kinase (RIP2). Fragment based screening and design principles led to the identification of the inhibitor series, and X-ray crystallography was used to inform key structural changes. Through key substitutions about the N1 and C5 N positions on the pyrazole ring significant kinase selectivity and potency were achieved. Bridged bicyclic pyrazolocarboxamide represents a selective and potent inhibitor of RIP2 and will allow for a more detailed investigation of RIP2 inhibition as a therapeutic target for autoinflammatory disorders.

PubMed: 31749904
DOI: 10.1021/acsmedchemlett.9b00141

実験手法

X-RAY DIFFRACTION (2.68 Å)