6UKU

STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 3

6UKU の概要

• エントリーDOI: 10.2210/pdb6uku/pdb
• 分子名称: fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain, 4,4'-[propane-1,3-diylbis(6-methoxy-1-benzothiene-5,2-diyl)]bis(4-oxobutanoic acid) (3 entities in total)
• 機能のキーワード: agonist, sting (stimulator of interferon genes), transmembrane protein 173 (tmem173), immune system, immune system-inhibitor complex, immune system-agonist complex
• 由来する生物種: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35025.19

構造登録者

Lesburg, C.A. (登録日: 2019-10-06, 公開日: 2020-08-19, 最終更新日: 2023-10-11)

• 主引用文献: Pan, B.S.,Perera, S.A.,Piesvaux, J.A.,Presland, J.P.,Schroeder, G.K.,Cumming, J.N.,Trotter, B.W.,Altman, M.D.,Buevich, A.V.,Cash, B.,Cemerski, S.,Chang, W.,Chen, Y.,Dandliker, P.J.,Feng, G.,Haidle, A.,Henderson, T.,Jewell, J.,Kariv, I.,Knemeyer, I.,Kopinja, J.,Lacey, B.M.,Laskey, J.,Lesburg, C.A.,Liang, R.,Long, B.J.,Lu, M.,Ma, Y.,Minnihan, E.C.,O'Donnell, G.,Otte, R.,Price, L.,Rakhilina, L.,Sauvagnat, B.,Sharma, S.,Tyagarajan, S.,Woo, H.,Wyss, D.F.,Xu, S.,Bennett, D.J.,Addona, G.H.; An orally available non-nucleotide STING agonist with antitumor activity.; Science, 369:-, 2020; PubMed: 32820094; DOI: 10.1126/science.aba6098

実験手法

X-RAY DIFFRACTION (1.68 Å)