6UIG

Crystal structure of human monoclonal antibody H7.200 in complex with H7N9 hemagglutinin HA1

6UIG の概要

• エントリーDOI: 10.2210/pdb6uig/pdb
• 分子名称: Hemagglutinin, H7.200 Fab heavy chain, H7.200 Fab light chain, ... (4 entities in total)
• 機能のキーワード: influenza a, monoclonal antibody, antiviral protein
• 由来する生物種: Influenza A virus; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 163216.44

構造登録者

Dong, J.,Crowe, J.E. (登録日: 2019-09-30, 公開日: 2020-10-07, 最終更新日: 2024-10-30)

主引用文献

Dong, J.,Gilchuk, I.,Li, S.,Irving, R.,Goff, M.T.,Turner, H.L.,Ward, A.B.,Carnahan, R.H.,Crowe Jr., J.E.
Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface.
J.Clin.Invest., 130:4734-4739, 2020

PubMed Abstract: Although broadly protective, stem-targeted Abs against the influenza A virus hemagglutinin (HA) have been well studied, very limited information is available on Abs that broadly recognize the head domain. We determined the crystal structure of the HA protein of the avian H7N9 influenza virus in complex with a pan-H7, non-neutralizing, protective human Ab. The structure revealed a B cell epitope in the HA head domain trimer interface (TI). This discovery of a second major protective TI epitope supports a model in which uncleaved HA trimers exist on the surface of infected cells in a highly dynamic state that exposes hidden HA head domain features.

PubMed: 32749241
DOI: 10.1172/JCI136032

実験手法

X-RAY DIFFRACTION (3.2 Å)