6UGY

Crystal structure of the Fc fragment of anti-TNFa antibody infliximab (Remicade) in a primative orthorhombic crystal form, Lot C

Summary for 6UGY

Entry DOI	10.2210/pdb6ugy/pdb
Descriptor	Remicade Fc, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
Functional Keywords	antibody, biologic, biosimilar, infliximab, remicade, fragment crystallizable, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	30038.82
Authors	Mayclin, S.J.,Edwards, T.E. (deposition date: 2019-09-26, release date: 2019-11-13, Last modification date: 2023-10-11)
Primary citation	Lerch, T.F.,Sharpe, P.,Mayclin, S.J.,Edwards, T.E.,Polleck, S.,Rouse, J.C.,Zou, Q.,Conlon, H.D. Crystal Structures of PF-06438179/GP1111, an Infliximab Biosimilar. BioDrugs, 34:77-87, 2020 Cited by PubMed: 31650490 DOI: 10.1007/s40259-019-00390-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation