6UGY

Crystal structure of the Fc fragment of anti-TNFa antibody infliximab (Remicade) in a primative orthorhombic crystal form, Lot C

6UGY の概要

• エントリーDOI: 10.2210/pdb6ugy/pdb
• 分子名称: Remicade Fc, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
• 機能のキーワード: antibody, biologic, biosimilar, infliximab, remicade, fragment crystallizable, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30038.82

構造登録者

Mayclin, S.J.,Edwards, T.E. (登録日: 2019-09-26, 公開日: 2019-11-13, 最終更新日: 2023-10-11)

• 主引用文献: Lerch, T.F.,Sharpe, P.,Mayclin, S.J.,Edwards, T.E.,Polleck, S.,Rouse, J.C.,Zou, Q.,Conlon, H.D.; Crystal Structures of PF-06438179/GP1111, an Infliximab Biosimilar.; BioDrugs, 34:77-87, 2020; PubMed: 31650490; DOI: 10.1007/s40259-019-00390-1

実験手法

X-RAY DIFFRACTION (2.1 Å)