6UGO

Human Carbonic Anhydrase IX-mimic complexed with SB4-205

6UGO の概要

• エントリーDOI: 10.2210/pdb6ugo/pdb
• 分子名称: Carbonic anhydrase IX-mimic, ZINC ION, 5,7-dimethyl-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione, ... (5 entities in total)
• 機能のキーワード: cyclical sulfonamide, inhibitor, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29780.75

構造登録者

Murray, A.B.,McKenna, R.,Lomelino, C.L. (登録日: 2019-09-26, 公開日: 2019-12-18, 最終更新日: 2023-10-11)

• 主引用文献: Bua, S.,Lomelino, C.,Murray, A.B.,Osman, S.M.,ALOthman, Z.A.,Bozdag, M.,Abdel-Aziz, H.A.,Eldehna, W.M.,McKenna, R.,Nocentini, A.,Supuran, C.T.; "A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.; J.Med.Chem., 63:321-333, 2020; PubMed: 31794211; DOI: 10.1021/acs.jmedchem.9b01669

実験手法

X-RAY DIFFRACTION (1.457 Å)