6UEA

Structure of pentameric sIgA complex

6UEA の概要

• エントリーDOI: 10.2210/pdb6uea/pdb
• EMDBエントリー: 20749 20750 20751 20752
• 分子名称: Immunoglobulin heavy constant alpha 2, Polymeric immunoglobulin receptor, Immunoglobulin J chain, ... (6 entities in total)
• 機能のキーワード: immunoglobulin, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 351486.66

構造登録者

Kumar, N.,Arthur, C.P.,Ciferri, C.,Matsumoto, M.L. (登録日: 2019-09-20, 公開日: 2020-02-19, 最終更新日: 2024-11-06)

主引用文献

Kumar, N.,Arthur, C.P.,Ciferri, C.,Matsumoto, M.L.
Structure of the secretory immunoglobulin A core.
Science, 367:1008-1014, 2020

PubMed Abstract: Secretory immunoglobulin A (sIgA) represents the immune system's first line of defense against mucosal pathogens. IgAs are transported across the epithelium, as dimers and higher-order polymers, by the polymeric immunoglobulin receptor (pIgR). Upon reaching the luminal side, sIgAs mediate host protection and pathogen neutralization. In recent years, an increasing amount of attention has been given to IgA as a novel therapeutic antibody. However, despite extensive studies, sIgA structures have remained elusive. Here, we determine the atomic resolution structures of dimeric, tetrameric, and pentameric IgA-Fc linked by the joining chain (JC) and in complex with the secretory component of the pIgR. We suggest a mechanism in which the JC templates IgA oligomerization and imparts asymmetry for pIgR binding and transcytosis. This framework will inform the design of future IgA-based therapeutics.

PubMed: 32029686
DOI: 10.1126/science.aaz5807

実験手法

ELECTRON MICROSCOPY (3 Å)