6UBW

MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody

「5UAF」から置き換えられました

6UBW の概要

• エントリーDOI: 10.2210/pdb6ubw/pdb
• 分子名称: Hepatocyte growth factor receptor, N-(6-{difluoro[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]methyl}imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: met, tyrosine kinase, inhibitor, antitumor, transferase-transferase inhibitor complex, transferase-transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39063.37

構造登録者

Hoffman, I.D.,Lawson, J.D. (登録日: 2019-09-13, 公開日: 2020-02-12, 最終更新日: 2021-08-25)

• 主引用文献: Farrell, P.J.,Matuszkiewicz, J.,Balakrishna, D.,Pandya, S.,Hixon, M.S.,Kamran, R.,Chu, S.,Lawson, J.D.,Okada, K.,Hori, A.,Mizutani, A.,Iwata, H.,de Jong, R.,Hibner, B.,Vincent, P.; MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody.; Mol.Cancer Ther., 16:1269-1278, 2017; PubMed: 28341789; DOI: 10.1158/1535-7163.MCT-16-0771

実験手法

X-RAY DIFFRACTION (2 Å)