6UA4

Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Bent (3/4 compressed, 1/4 extended) segment reconstruction.

Summary for 6UA4

Entry DOI	10.2210/pdb6ua4/pdb
EMDB information	20705
Descriptor	Inosine-5'-monophosphate dehydrogenase 2, GUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	metabolism, filament, allostery, adenine, guanine, biosynthetic protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	16
Total formula weight	923131.02
Authors	Johnson, M.C.,Kollman, J.M. (deposition date: 2019-09-10, release date: 2020-03-25, Last modification date: 2024-03-20)
Primary citation	Johnson, M.C.,Kollman, J.M. Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9:-, 2020 Cited by PubMed: 31999252 DOI: 10.7554/eLife.53243 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.65 Å)

Structure validation