6U95
Adeno-associated virus strain AAVhu.37 capsid icosahedral structure
Summary for 6U95
| Entry DOI | 10.2210/pdb6u95/pdb |
| EMDB information | 20693 |
| Descriptor | Capsid protein VP1 (1 entity in total) |
| Functional Keywords | capsid, blood-brain barrier penetration, virus |
| Biological source | Adeno-associated virus |
| Total number of polymer chains | 1 |
| Total formula weight | 81528.85 |
| Authors | Kaelber, J.T.,Yost, S.A.,Firlar, E.,Mercer, A.C. (deposition date: 2019-09-06, release date: 2019-09-18, Last modification date: 2024-03-20) |
| Primary citation | Kaelber, J.T.,Yost, S.A.,Webber, K.A.,Firlar, E.,Liu, Y.,Danos, O.,Mercer, A.C. Structure of the AAVhu.37 capsid by cryoelectron microscopy. Acta Crystallogr.,Sect.F, 76:58-64, 2020 Cited by PubMed Abstract: Adeno-associated viruses (AAVs) are used as in vivo gene-delivery vectors in gene-therapy products and have been heavily investigated for numerous indications. Over 100 naturally occurring AAV serotypes and variants have been isolated from primate samples. Many reports have described unique properties of these variants (for instance, differences in potency, target cell or evasion of the immune response), despite high amino-acid sequence conservation. AAVhu.37 is of interest for clinical applications owing to its proficient transduction of the liver and central nervous system. The sequence identity of the AAVhu.37 VP1 to the well characterized AAVrh.10 serotype, for which no structure is available, is greater than 98%. Here, the structure of the AAVhu.37 capsid at 2.56 Å resolution obtained via single-particle cryo-electron microscopy is presented. PubMed: 32039886DOI: 10.1107/S2053230X20000308 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.56 Å) |
Structure validation
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