6U8D

Crystal structure of hepatitis C virus IRES junction IIIabc in complex with Fab HCV2

6U8D の概要

• エントリーDOI: 10.2210/pdb6u8d/pdb
• 分子名称: JIIIabc RNA (68-MER), Heavy chain of Fab HCV2, Light chain of Fab HCV2, ... (4 entities in total)
• 機能のキーワード: internal ribosome entry site (ires), hepatitis c virus, junction iiiabc, antibody-assisted rna crystallography, viral translation, viral rna domains, rna, rna-immune system complex, rna/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 70444.93

構造登録者

Koirala, D.,Lewicka, A.,Koldobskaya, Y.,Huang, H.,Piccirilli, J.A. (登録日: 2019-09-04, 公開日: 2019-12-04, 最終更新日: 2023-10-11)

• 主引用文献: Koirala, D.,Lewicka, A.,Koldobskaya, Y.,Huang, H.,Piccirilli, J.A.; Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation.; Acs Chem.Biol., 15:205-216, 2020; PubMed: 31765566; DOI: 10.1021/acschembio.9b00785

実験手法

X-RAY DIFFRACTION (1.807 Å)