6U85

Site-specific lysine arylation as an alternative bioconjugation strategy for chemically programmed antibodies and antibody-drug conjugates

6U85 の概要

• エントリーDOI: 10.2210/pdb6u85/pdb
• 分子名称: Antibody Fab heavy chain, antibody Fab Light chain, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: single chain fv, scfv, antibody, ror2, kringle domain, receptor tyrosine kinase-like orphan receptor, phage display, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48077.60

構造登録者

Park, H.,Rader, C. (登録日: 2019-09-04, 公開日: 2019-11-13, 最終更新日: 2023-10-11)

• 主引用文献: Hwang, D.,Tsuji, K.,Park, H.,Burke Jr., T.R.,Rader, C.; Site-Specific Lysine Arylation as an Alternative Bioconjugation Strategy for Chemically Programmed Antibodies and Antibody-Drug Conjugates.; Bioconjug.Chem., 30:2889-2896, 2019; PubMed: 31675216; DOI: 10.1021/acs.bioconjchem.9b00609

実験手法

X-RAY DIFFRACTION (2.78 Å)