6U3I
Design of organo-peptides as bipartite PCSK9 antagonists
Summary for 6U3I
Entry DOI | 10.2210/pdb6u3i/pdb |
Related | 5VLP |
Descriptor | Proprotein convertase subtilisin/kexin type 9, cis-1-amino-4-phenylcyclohexaneacyl-WNLK(hR)I(D-ser)LLR - NH2, 7G7 heavy chain, ... (6 entities in total) |
Functional Keywords | inhibitor, complex, hydrolase-hydrolase inhibitor-immune system complex, hydrolase/hydrolase inhibitor/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 124899.36 |
Authors | Ultsch, M.H.,Kirchhofer, D. (deposition date: 2019-08-21, release date: 2020-02-05, Last modification date: 2023-11-15) |
Primary citation | Burdick, D.J.,Skelton, N.J.,Ultsch, M.,Beresini, M.H.,Eigenbrot, C.,Li, W.,Zhang, Y.,Nguyen, H.,Kong-Beltran, M.,Quinn, J.G.,Kirchhofer, D. Design of Organo-Peptides As Bipartite PCSK9 Antagonists. Acs Chem.Biol., 15:425-436, 2020 Cited by PubMed: 31962046DOI: 10.1021/acschembio.9b00899 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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