6U0Q

Transthyretin in complex with (E)-5,5'-(ethene-1,2-diyl)bis(1,1-dihydroxy-3-oxo-1,3-dihydrobenzo[c][1,2]oxaborol-1-uide)

Summary for 6U0Q

• Entry DOI: 10.2210/pdb6u0q/pdb
• Descriptor: Transthyretin, 3-[(~{E})-2-[7,7-bis(oxidanyl)-9-oxidanylidene-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-3-yl]ethenyl]-7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-9-one (3 entities in total)
• Functional Keywords: ttr, boronic acid, covalent inhibitor, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 28524.88

Authors

Windsor, I.W.,Graham, B.J.,Raines, R.T. (deposition date: 2019-08-14, release date: 2021-01-27, Last modification date: 2023-10-11)

• Primary citation: Graham, B.J.,Windsor, I.W.,Gold, B.,Raines, R.T.; Boronic acid with high oxidative stability and utility in biological contexts.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 33653951; DOI: 10.1073/pnas.2013691118

Experimental method

X-RAY DIFFRACTION (1.75 Å)