6U0D

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZL0590

6U0D の概要

• エントリーDOI: 10.2210/pdb6u0d/pdb
• 分子名称: Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, N-[4-({(2S)-2-[(morpholin-4-yl)methyl]pyrrolidin-1-yl}sulfonyl)phenyl]-N'-[4-(trifluoromethyl)phenyl]urea, ... (4 entities in total)
• 機能のキーワード: bromodomain, inhibitor, complex, gene regulation
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15690.06

構造登録者

Leonard, P.G.,Joseph, S. (登録日: 2019-08-14, 公開日: 2020-08-19, 最終更新日: 2023-10-11)

• 主引用文献: Liu, Z.,Li, Y.,Chen, H.,Lai, H.,Wang, P.,Wu, S.,Wold, E.A.,Leonard, P.G.,Joseph, S.,Hu, H.,Chiang, C.,Brasier, A.R.,Tian, B.,Zhou, J.; Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site; J. Med. Chem., 2022; DOI: 10.1021/acs.jmedchem.1c01851

実験手法

X-RAY DIFFRACTION (1.43 Å)