6TZV

Crystal Structure of the carboxyltransferase subunit of ACC (AccD6) in complex with inhibitor Phenyl-Cyclodiaone from Mycobacterium tuberculosis

Summary for 6TZV

• Entry DOI: 10.2210/pdb6tzv/pdb
• Related: 6PRW
• Descriptor: Probable propionyl-CoA carboxylase beta chain 6, 4'-[(6-chloro-1,3-benzothiazol-2-yl)oxy]-6-hydroxy-4,4-dimethyl-4,5-dihydro[1,1'-biphenyl]-2(3H)-one (3 entities in total)
• Functional Keywords: transferase inhibitor accd6, carboxyltransferase beta-subunit of acyl-coacarboxylase, structural genomics, tb structural genomics consortium, tbsgc, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 8
• Total formula weight: 404790.60

Authors

Reddy, M.C.M.,Zhou, N.,Sacchettini, J.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2019-08-13, release date: 2020-08-19, Last modification date: 2024-03-13)

• Primary citation: Reddy, M.C.M.,Zhou, N.,Sacchettini, J.; Novel herbicidal derivatives that inhibit carboxyltransferase subunit of the acetyl-CoA carboxylase in Mycobacterium tuberculosis; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.388 Å)