6TZ7

Crystal Structure of Aspergillus fumigatus Calcineurin A, Calcineurin B, FKBP12 and FK506 (Tacrolimus)

6TZ7 の概要

• エントリーDOI: 10.2210/pdb6tz7/pdb
• 分子名称: Serine/threonine-protein phosphatase 2B catalytic subunit, Calcineurin Ca2+-binding regulatory subunit CnaB, FK506-binding protein 1A, ... (10 entities in total)
• 機能のキーワード: calcineurin, fk506, hydrolase-isomerase-calcium binding complex, hydrolase/isomerase/calcium binding
• 由来する生物種: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 79808.44

構造登録者

Fox III, D.,Horanyi, P.S. (登録日: 2019-08-10, 公開日: 2019-09-18, 最終更新日: 2023-10-11)

• 主引用文献: Juvvadi, P.R.,Fox 3rd, D.,Bobay, B.G.,Hoy, M.J.,Gobeil, S.M.C.,Venters, R.A.,Chang, Z.,Lin, J.J.,Averette, A.F.,Cole, D.C.,Barrington, B.C.,Wheaton, J.D.,Ciofani, M.,Trzoss, M.,Li, X.,Lee, S.C.,Chen, Y.L.,Mutz, M.,Spicer, L.D.,Schumacher, M.A.,Heitman, J.,Steinbach, W.J.; Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.; Nat Commun, 10:4275-4275, 2019; PubMed: 31537789; DOI: 10.1038/s41467-019-12199-1

実験手法

X-RAY DIFFRACTION (2.5 Å)