6TXF
Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dAMPNPP and Mn
Summary for 6TXF
Entry DOI | 10.2210/pdb6txf/pdb |
Related | 6TX0 6TXA 6TXC 6TXE |
Descriptor | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, MANGANESE (II) ION, ... (6 entities in total) |
Functional Keywords | triphosphohydrolase, metallo-enzyme, binuclear, hd, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 123866.07 |
Authors | Morris, E.R.,Kunzelmann, S.,Caswell, S.J.,Arnold, L.H.,Purkiss, A.G.,Kelly, G.,Taylor, I.A. (deposition date: 2020-01-14, release date: 2020-06-24, Last modification date: 2024-01-24) |
Primary citation | Morris, E.R.,Caswell, S.J.,Kunzelmann, S.,Arnold, L.H.,Purkiss, A.G.,Kelly, G.,Taylor, I.A. Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11:3165-3165, 2020 Cited by PubMed: 32576829DOI: 10.1038/s41467-020-16983-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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