6TVG

Human CD73 (ecto 5'-nucleotidase) in complex with AMPCP in the open state

6TVG の概要

• エントリーDOI: 10.2210/pdb6tvg/pdb
• 分子名称: 5'-nucleotidase, ecto (CD73), isoform CRA_a, ZINC ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (6 entities in total)
• 機能のキーワード: en, e5nt, ecto-nucleotidase, nucleotide, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61083.45

構造登録者

Scaletti, E.,Strater, N. (登録日: 2020-01-09, 公開日: 2020-02-26, 最終更新日: 2024-01-24)

• 主引用文献: Bhattarai, S.,Pippel, J.,Scaletti, E.,Idris, R.,Freundlieb, M.,Rolshoven, G.,Renn, C.,Lee, S.Y.,Abdelrahman, A.,Zimmermann, H.,El-Tayeb, A.,Muller, C.E.,Strater, N.; 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes.; J.Med.Chem., 63:2941-2957, 2020; PubMed: 32045236; DOI: 10.1021/acs.jmedchem.9b01611

実験手法

X-RAY DIFFRACTION (1.48 Å)