6TTU
Ubiquitin Ligation to substrate by a cullin-RING E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1 N98R-SKP1-monomeric b-TRCP1dD-IkBa-UB~UBE2D2
Summary for 6TTU
Entry DOI | 10.2210/pdb6ttu/pdb |
EMDB information | 10578 10579 10580 10581 10582 10583 10585 |
Descriptor | F-box/WD repeat-containing protein 1A, S-phase kinase-associated protein 1, Cullin-1, ... (9 entities in total) |
Functional Keywords | ubiquitin, e3 ligase, nedd8, cullin, cul1, rbx1, skp1, trcp, ube2d, ikbalpha, neddylation, ubiquitylation, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 227736.25 |
Authors | Baek, K.,Prabu, J.R.,Schulman, B.A. (deposition date: 2019-12-30, release date: 2020-02-12, Last modification date: 2020-03-04) |
Primary citation | Baek, K.,Krist, D.T.,Prabu, J.R.,Hill, S.,Klugel, M.,Neumaier, L.M.,von Gronau, S.,Kleiger, G.,Schulman, B.A. NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly. Nature, 578:461-466, 2020 Cited by PubMed: 32051583DOI: 10.1038/s41586-020-2000-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.7 Å) |
Structure validation
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