6TTP
Crystal structure of the human METTL3-METTL14 complex bound to Compound 1/Adenosine (DHU_M3M_023)
Summary for 6TTP
Entry DOI | 10.2210/pdb6ttp/pdb |
Descriptor | N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, ADENOSINE, ... (5 entities in total) |
Functional Keywords | compound, complex, mettl3, mettl14, epitranscriptomic, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 117118.61 |
Authors | Bedi, R.K.,Huang, D.,Sledz, P.,Caflisch, A. (deposition date: 2019-12-30, release date: 2020-03-04, Last modification date: 2024-01-24) |
Primary citation | Bedi, R.K.,Huang, D.,Eberle, S.A.,Wiedmer, L.,Sledz, P.,Caflisch, A. Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer. Chemmedchem, 15:744-748, 2020 Cited by PubMed: 32159918DOI: 10.1002/cmdc.202000011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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