6TTK

Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide

Summary for 6TTK

• Entry DOI: 10.2210/pdb6ttk/pdb
• Descriptor: Kelch-like protein 12, DVL1, SODIUM ION, ... (6 entities in total)
• Functional Keywords: cullin3 e3 ligase, kelch, complex, substrate peptide, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 137511.49

Authors

Chen, Z.,Williams, E.,Pike, A.C.W.,Strain-Damerell, C.,Wang, D.,Chalk, R.,Burgess-Brown, N.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2019-12-27, release date: 2020-02-12, Last modification date: 2024-01-24)

• Primary citation: Chen, Z.,Wasney, G.A.,Picaud, S.,Filippakopoulos, P.,Vedadi, M.,D'Angiolella, V.,Bullock, A.N.; Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.; Open Biology, 10:200041-200041, 2020; PubMed: 32574548; DOI: 10.1098/rsob.200041

Experimental method

X-RAY DIFFRACTION (2.383 Å)