6TTK

Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide

6TTK の概要

• エントリーDOI: 10.2210/pdb6ttk/pdb
• 分子名称: Kelch-like protein 12, DVL1, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: cullin3 e3 ligase, kelch, complex, substrate peptide, ligase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 137511.49

構造登録者

Chen, Z.,Williams, E.,Pike, A.C.W.,Strain-Damerell, C.,Wang, D.,Chalk, R.,Burgess-Brown, N.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (登録日: 2019-12-27, 公開日: 2020-02-12, 最終更新日: 2024-01-24)

• 主引用文献: Chen, Z.,Wasney, G.A.,Picaud, S.,Filippakopoulos, P.,Vedadi, M.,D'Angiolella, V.,Bullock, A.N.; Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.; Open Biology, 10:200041-200041, 2020; PubMed: 32574548; DOI: 10.1098/rsob.200041

実験手法

X-RAY DIFFRACTION (2.383 Å)