6TTH

PKM2 in complex with L-threonine

Summary for 6TTH

Entry DOI	10.2210/pdb6tth/pdb
EMDB information	10575 10576
Descriptor	Pyruvate kinase PKM, 1,6-di-O-phosphono-beta-D-fructofuranose, THREONINE, ... (4 entities in total)
Functional Keywords	pkm2, fbdd, l-threonine, cytosolic protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	241164.22
Authors	Saur, M.,Hartshorn, M.J.,Dong, J.,Reeks, J.,Bunkoczi, G.,Jhoti, H.,Williams, P.A. (deposition date: 2019-12-27, release date: 2020-01-15, Last modification date: 2024-05-22)
Primary citation	Saur, M.,Hartshorn, M.J.,Dong, J.,Reeks, J.,Bunkoczi, G.,Jhoti, H.,Williams, P.A. Fragment-based drug discovery using cryo-EM. Drug Discov Today, 25:485-490, 2020 Cited by PubMed: 31877353 DOI: 10.1016/j.drudis.2019.12.006 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.6 Å)

Structure validation