6TSF
Crystal structure of human L ferritin (HuLf) Fe(III)-loaded for 60 minutes
This is a non-PDB format compatible entry.
Summary for 6TSF
| Entry DOI | 10.2210/pdb6tsf/pdb |
| Related | 6TR9 6TRZ 6TS0 6TS1 6TSA |
| Descriptor | Ferritin light chain, FE (III) ION, CADMIUM ION, ... (5 entities in total) |
| Functional Keywords | human l ferritin, hulf, fe(iii), trinuclear fe(iii) cluster, metal binding protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 20935.08 |
| Authors | Pozzi, C.,Ciambellotti, S.,Turano, P.,Mangani, S. (deposition date: 2019-12-20, release date: 2020-02-19, Last modification date: 2024-01-24) |
| Primary citation | Ciambellotti, S.,Pozzi, C.,Mangani, S.,Turano, P. Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin. Chemistry, 26:5770-5773, 2020 Cited by PubMed Abstract: X-ray structures of homopolymeric human L-ferritin and horse spleen ferritin were solved by freezing protein crystals at different time intervals after exposure to a ferric salt and revealed the growth of an octa-nuclear iron cluster on the inner surface of the protein cage with a key role played by some glutamate residues. An atomic resolution view of how the cluster formation develops starting from a (μ -oxo)tris[(μ -glutamato-κO:κO')](glutamato-κO)(diaquo)triiron(III) seed is provided. The results support the idea that iron biomineralization in ferritin is a process initiating at the level of the protein surface, capable of contributing coordination bonds and electrostatic guidance. PubMed: 32027764DOI: 10.1002/chem.202000064 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
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